Applied DNA Gets Contract from HDT Bio for Vaccine Development

Applied DNA Gets Contract from HDT Bio for Vaccine Development

By, Admin 29 April 2024

Applied DNA gets contract from HDT Bio for vaccine development under a ‘Project NextGen: Enabler’

Overview

Applied DNA Sciences, Inc. (Applied DNA), a leader in PCR-based DNA technologies, announced the award of a contract from HDT Bio for the purpose of rapid, next-generation vaccine development under a ‘Project NextGen: Enabler’ award to HDT Bio (the “Project”). The Project seeks to facilitate the rapid production of vaccines during outbreaks/pandemics, focusing on decentralized vaccine manufacturing, with vaccines deemed critical medical countermeasures to infectious disease threats.

Terms of The Contract

  • Under the terms of the contract, Applied DNA will supply Linea DNA IVT templates to HDT Bio for use in conjunction with its LION formulated repRNA (self-replicating RNA) vaccination platform. 
  • The goal of the contract is to demonstrate the feasibility of manufacturing 1,000 doses of a functional vaccine within seven days.

Linea DNA Platform

  • The Linea DNA platform is a completely cell-free DNA production platform founded on Applied DNA's long-standing expertise in the large-scale enzymatic production of DNA. 
  • Capable of producing DNA in quantities ranging from milligrams to grams, the Linea DNA platform can produce high-fidelity DNA constructs ranging from 100bp to 20kb in size. 
  • The DNA produced via the Linea DNA platform is free of the adventitious DNA sequences found in other sources of DNA, is rapidly scalable, and provides for simple chemical modification of DNA constructs.

Linea IVT Platform

  • The Linea IVT platform combines DNA IVT templates manufacturing via the Linea DNA platform with a proprietary Linea RNAP to enable mRNA and sa-mRNA manufacturers to produce what Applied DNA believes to be better mRNA faster, with advantages over conventional

mRNA production, including:

1) the elimination of plasmid DNA as a starting material; 
2) the prevention or reduction of double-stranded DNA (dsRNA) contamination; and 
3) simplified mRNA production workflows.

HDT Bio

  • HDT Bio is a Seattle-based, clinical-stage biopharmaceutical development company. 
  • With core technology and expertise in nucleic acid formulation, the company develops products that seek to harness host-directed immune responses.

Applied DNA Sciences

Applied DNA Sciences is a biotechnology company developing technologies to produce and detect deoxyribonucleic acid (DNA).

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