Eisai And Seikagaku Enter Into Agreement For The Co-Development And Marketing Alliance Of Si-613 A Treatment Of Osteoarthritis In China

Eisai And Seikagaku Enter Into Agreement For The Co-Development And Marketing Alliance Of Si-613 A Treatment Of Osteoarthritis In China

Eisai Co., Ltd. And Seikagaku Announced Today That The Companies Have Entered Into An Agreement For The Co-Development And Marketing Alliance In China For Si-613 (Diclofenac Conjugated Sodium Hyaluronate), A Therapeutic Agent For Osteoarthritis Discovered By Seikagaku.On The Basis Of This Agreement, The Companies Will Jointly Develop Si-613 In China For A Treatment Of Knee Osteoarthritis. After Obtaining Approval, Seikagaku Will Supply Products To Eisai, And Eisai Will Be Responsible For Distribution. The Companies Will Cover An Equal Share Of The Development Cost, And Eisai Will Pay Seikagaku The Upfront Payment, And Development As Well As Sales Milestones.Osteoarthritis Is A Disease Caused By The Articular Cartilage Damage Due To Aging And Other Factors, Leading To Inflammation And Pain, Which Result In Impaired Quality Of Life (Qol). Knee Osteoarthritis Is One Of The Most Frequent Cases Among Thereof, And The Number Of Symptomatic Patients With Knee Osteoarthritis In China Is Estimated To Be Approximately 47 Million(1), And It Is Anticipated That The Number Will Continue To Increase As The Population Ages.Si-613 Is Diclofenac Conjugated Sodium Hyaluronate Created By Seikagaku Using Their Proprietary Drug-Binding Technology To Chemically Bond Hyaluronic Acid And Diclofenac (An Anti-Inflammatory Drug).This Material Has The Analgesic And Anti-Inflammatory Effects Of Diclofenac, Which Is Designed To Be 23 Sustained-Released(2) By A Drug Delivery System(3), In Addition To The Joint Function Improving Effect Of Sodium Hyaluronate. Hence, It Is Expected That Si-613 Rapidly And Continuously Reduces The Pain And Inflammation Associated With Osteoarthritis.

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