Eisai to Present New Lecanemab Data at AD/PD 2026 Conference

Eisai Co., Ltd. will present new research on Lecanemab, its therapy for Alzheimer's disease, at the International Conference on Alzheimer's and Parkinson's Diseases and Related Neurological Disorders 2026.

The conference will take place March 17–21, 2026, in Copenhagen and online. Eisai plans to present six research updates, including three oral presentations and several poster sessions, highlighting real-world data and long-term outcomes associated with lecanemab.

Focus on Real-World Outcomes and Long-Term Data

The upcoming presentations will emphasize real-world clinical evidence and long-term treatment outcomes for patients receiving lecanemab.

Key oral presentations will cover:

• Safety and effectiveness of lecanemab in APOE4 homozygous patients based on data from the LEADER real-world study
• Long-term treatment persistence and patient characteristics among individuals using lecanemab in routine clinical practice in the United States
• A genome-wide association study identifying genetic variants linked to cognitive decline in Alzheimer’s disease

These findings aim to deepen understanding of how anti-amyloid therapies perform outside controlled clinical trials.

Additional Poster Presentations

Four additional studies will be presented as posters at the conference.

Highlights include:

• 48-month results from the Clarity AD open-label extension study, focusing on patients who are APOE ε4 non-carriers and heterozygotes
• Research examining how lecanemab reduces amyloid-beta protofibrils and how these reductions correlate with biomarkers linked to neuronal and synaptic health
• Development of a fully automated plasma pTau205 immunoassay, created in collaboration with Sysmex Corporation

Poster sessions will be available for viewing March 17–19 (CET).

Industry Symposium on Early Alzheimer’s Intervention

Eisai will also host a sponsored symposium titled:

“Continue Life Their Way: Early Intervention in Alzheimer’s Disease.”

The session will feature global experts discussing several key topics:

• Why early intervention is critical in Alzheimer’s disease
• Long-term evidence supporting continued treatment in early disease stages
• How real-world data can guide clinical decision-making

The symposium aims to highlight the importance of recognizing Alzheimer’s disease as a chronic condition requiring multidisciplinary care.

About Lecanemab (LEQEMBI)

Lecanemab is a humanized monoclonal antibody designed to target amyloid-beta protofibrils, toxic protein aggregates believed to play a key role in Alzheimer’s disease progression.

By targeting these aggregates, the therapy aims to:

• Reduce amyloid buildup in the brain
• Limit neuronal damage
• Slow cognitive decline

The therapy emerged from a long-standing research collaboration between Eisai Co., Ltd. and BioArctic AB.

Global Approvals and Regulatory Progress

Lecanemab has already received approval in more than 50 countries and regions, including:

• United States
• Japan
• China
• European Union
• South Korea
• Saudi Arabia

Recent regulatory developments include:

• U.S. FDA approval of subcutaneous maintenance dosing (August 2025)
• Priority Review for a supplemental Biologics License Application, with a decision expected May 24, 2026
• Ongoing regulatory review of a subcutaneous formulation in multiple countries

Ongoing Clinical Research

Several major clinical trials continue to investigate lecanemab’s potential.

One of the most notable is the AHEAD 3‑45 trial, which focuses on individuals with preclinical Alzheimer’s disease who have elevated amyloid levels but no cognitive symptoms.

The trial is conducted through a public-private partnership involving:

• Alzheimer's Clinical Trial Consortium
• National Institute on Aging
• Eisai Co., Ltd.
• Biogen Inc.

Another ongoing program is the Tau NexGen study, which investigates treatments for dominantly inherited Alzheimer’s disease.

Advancing Alzheimer’s Treatment Strategies

The upcoming presentations at AD/PD 2026 reflect growing interest in real-world evidence, biomarker development, and long-term treatment outcomes for Alzheimer’s disease therapies.

As research continues, therapies like lecanemab may help refine early intervention strategies, potentially improving long-term outcomes for patients living with this progressive neurodegenerative condition.

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