Elpiscience Announces First Patient Dosed for Phase 1 Clinical Trial of First-in-Class Anti-CD39xTGF-? Bispecific Antibody ES014

Elpiscience Announces First Patient Dosed for Phase 1 Clinical Trial of First-in-Class Anti-CD39xTGF-? Bispecific Antibody ES014

By, Admin 28 February 2023

Elpiscience Biopharma, Inc. a clinical-stage biopharmaceutical company dedicated to developing life-changing immuno-oncology therapies for cancer patients worldwide, today announced that the first patient has been dosed in a Phase 1 clinical trial of ES014, a first-in-class anti-CD39xTGF-? bispecific antibody (bsAb). The principal investigator of the study is Professor Lu Shun, Director of Oncology Department of Shanghai Chest Hospital. ES014 simultaneously targets the CD39-adenosine and TGF-? pathways, aiming to convert the immunosuppressive tumor microenvironment (TME) into an immune-friendly one. Adenosine and TGF-? are two key immunosuppressive pathways within the TME. TGF-?, frequently expressed on solid tumors, suppresses T cell activation and induces CD39 expression, the rate-limiting enzyme in the ATP-adenosine pathway. ES014 is designed to have the following functions: 1. It blocks suppressive adenosine generation through CD39 inhibition while maintaining high levels of immune-stimulatory extracellular ATP, the substrate of CD39; 2. ES014 simultaneously neutralizes TGF-?, leading to activation of T cells and blockade of Treg differentiation while avoiding or minimizing systemic immunotoxicity.

Optimize Your trial insights with Clival Database.

Are you exhausted from the uncertainty of trial insights pricing? Clival Database ensures the clarity in the midst of the global scenario for clinical trials to you.

Clival Database is one of the best databases that offers an outstanding number of clinical trial data in terms of 50,000+ molecules and from primary regulatory markets as well as new entrants like Indian and Chinese markets.

With Clival, you get accurate positioning of historical sales data, patent database, company profiling, safety & efficacy, and prediction of launch of new innovative molecules helping you to align your research and driving down the cost.

To add value, we further break down our analytics for you so that improving your operational effectiveness; optimizing your clinical trials; and offering you accurate and high-quality data at lowest possible prices becomes possible.

Elevate your trial success rate with the cutting-edge insights from Clival database.

Check it out today and make more informed sourcing decisions! Learn More!