Oxford Bio collaborates with Agenus to support clinical development of OBTs antibody drug conjugate OBT076 in combo with Agenus CPI balstilimab

Oxford Bio collaborates with Agenus to support clinical development of OBTs antibody drug conjugate OBT076 in combo with Agenus CPI balstilimab

By, Admin 27 May 2022

Oxford BioTherapeutics (OBT), a clinical stage oncology company, announced that it has entered into a collaboration and supply agreement with Agenus Inc., an immuno-oncology company with an extensive pipeline of therapeutics designed to activate immune response to cancers and infections, to support a clinical trial evaluating the combination of OBT076 with the anti-PD1 checkpoint inhibitor (CPI) balstilimab. OBT has observed near complete responses in two chemotherapy-refractory advanced cancer patients with low to no PD-L1 expression after 2-5 cycles of OBT076 and 1-2 cycles of a CPI, indicating preliminary signs of clinical activity. Immuno-blood profiling during translational work on these patients revealed a potential novel immuno-oncology mechanism for immune system reactivation and tumour shrinkage. OBT plans to evaluate the clinical efficacy of OBT076 in combination with Agenus

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