Roche Launches Ocrevus in India

Roche Launches Ocrevus in India

By, Admin 29 February 2024

Roche launches Ocrevus for multiple sclerosis treatment in India

Overview

Roche Pharma India today announced the launch of its blockbuster breakthrough drug, Ocrevus (ocrelizumab), for the treatment of multiple sclerosis (MS), expanding its neurology portfolio to cater to unmet needs of numerous patients grappling with this debilitating disease in India. The majority of individuals are diagnosed with multiple sclerosis between the ages of 20 and 40, making the disease a leading cause of non-traumatic disability in younger adults. 

Unique drug for RRMS and PPMS

It is the only monoclonal antibody drug approved for the treatment of both RRMS and PPMS with more than 10 years of clinical and Real world data that highlights:

  • Over 80% of people with RRMS and over 33% of people with PPMS treated with Ocrevus showed no signs of disability progression. Starting Ocrevus two years earlier saved almost 10 years of disease progression in people with RRMS. Around 92% of people with RRMS who received Ocrevus earlier, did not need a walking aid and 80% of people with PPMS did not require a wheelchair after 10 years of initiating and continuous therapy with Ocrevus
  • Patients on Ocrevus have the highest persistence and superior adherence to treatment because of its twice yearly (once every six months) dosing which is preferable for most patients compared to more frequent (monthly) injections. ~80% of patients adhered to the twice-yearly dosing of Ocrevus after their second year of treatment compared with other DMTs.

  • Ocrevus is the only MS treatment that has demonstrated a consistent and significant impact on slowing disability progression across the spectrum of MS. It is the first and only approved therapy for both PPMS & RMS with more than 300,000+ patients treated globally. 

Words from Roche Pharma

  • Commenting on the launch, V Simpson Emmanuel, CEO and managing director, Roche Pharma India said, “The introduction of Ocrevus represents a pivotal moment in the management of multiple sclerosis in India. 
  • Boasting formidable efficacy, streamlined administration, and a commendable long-term safety record, Ocrevus instils fresh optimism in individuals grappling with this formidable neurological condition. 
  • As a blockbuster drug and Roche's flagship globally, launch of Ocrevus in India underscores our commitment to providing innovative solutions to address the burden of neurological disorders that is already one of the biggest health challenges globally and is only set to grow significantly."
  • Padma Shri Dr. (Prof.) M.V Padma Srivastava, chairperson, neurology- Paras Hospitals said, “This latest unveiling by Roche is distinct from existing therapies for MS. In the face of ongoing advancements, there remains a critical need for medications that can effectively manage disease activity and impede disability progression. 
  • Despite seemingly stable clinical symptoms, individuals with all forms of MS encounter underlying disease activity, marked by inflammation in the nervous system and irreversible loss of nerve cells in the brain. 
  • The paramount objective in MS treatment is to promptly reduce disease activity, thereby slowing the pace of disability progression. For those with relapsing MS (RMS) who persist in experiencing disease activity and worsening disability despite available treatments, ocrelizumab emerges as a breakthrough solution. I also strongly recommend early initiation of such treatment for better outcome.” 

MSSI on MS Treatment Therapy

  • Multiple Sclerosis Society of India (MSSI) National Honorary secretary Sandeep Chitnis said: “Detecting and diagnosing MS is often challenging due to the sporadic nature of early symptoms, the presence of similar warning signs in other central nervous system diseases, and the absence of a conclusive neurological or laboratory test for MS confirmation. 
  • Initiating treatment at the earliest stages with a therapy that addresses progression, and not just relapses, becomes imperative to safeguard the physical and mental capabilities of individuals with MS. 
  • This approach aims to minimize the impact of the disease on their daily lives and extend their independence for as long as possible. 

Words from Roche CMO

  • Dr. Viraj Suvarna, chief medical officer at Roche Pharma India said, “Ocrevus heralds a transformative era in multiple sclerosis treatment, signifying a paradigm shift from the moment of diagnosis. 
  • The extensive clinical trial data for Ocrevus stands as the most substantial evidence for any medication in significantly slowing disability progression in primary progressive MS. 
  • Moreover, it reveals superior outcomes in terms of brain atrophy and disability progression for early initiators of Ocrevus compared to those who switched to the drug after receiving interferon treatment for relapsing MS (RMS). 
  • These findings strongly advocate for the adoption of Ocrevus as the first line of treatment and the established standard of care across the entire spectrum of MS. 

About Ocrevus

Ocrevus is Roche’s leading product globally and is currently available in 100+ countries.  In India, the product is approved for both relapsing and primary progressive forms of multiple sclerosis. 

About Ocrelizumab

  • Ocrelizumab, a humanized monoclonal antibody, is a groundbreaking therapy for multiple sclerosis (MS), selectively targeting CD20+ B cells to modulate the immune response. 
  • With an impressive long-term efficacy and safety profile spanning up to 10 years, ocrelizumab's potent Antibody-Dependent Cellular Cytotoxicity (ADCC) and minimal Complement-Dependent Cytotoxicity (CDC) fortify the patient's immune system while reducing off-target effects. 
  • Its bi-annual, 2-hour infusion regimen promotes high adherence and eliminates the need for routine monitoring between doses. 
  • Furthermore, it significantly reduced the risk of transitioning to major disability milestones (EDSS =4.0 and EDSS =6.0) by approximately 60% compared to IFN ß-1a.

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