Verb Biotics Clinical Trial Shows Probiotic Can Improve Sleep and Reduce Stress

Verb Biotics Clinical Trial Shows Probiotic Can Improve Sleep and Reduce Stress

By, Admin 21 January 2026

A new U.S. consumer health survey by Verb Biotics, covering 2,000 adults, found that 73% experience mental health–related symptoms, including stress and poor sleep. Among them, 40% reported these symptoms interfere with daily functioning, underlining growing demand for natural, clinically validated solutions.

Clinical trial published in Scientific Reports

Verb Biotics has now published results from a human clinical trial in Nature Scientific Reports demonstrating that its proprietary probiotic strain, GABA Probiotic LP815®, significantly improves sleep quality and reduces stress.

The double-blind, randomized, placebo-controlled trial involved 138 participants.

What the study showed?

Participants who received LP815 experienced measurable improvements across multiple sleep and stress markers. Key outcomes included:

  • Improved overall sleep quality
  • Faster sleep onset
  • Increased total sleep and deep sleep duration
  • Reduced stress levels

These effects were observed without any reported gastrointestinal side effects.

Key clinical findings at a glance

  • 77.3% of participants showed a ≥4-point improvement in sleep scores by week 6
  • 100% of women participants reported improved sleep by week 6
  • Wearable data (Oura Ring) confirmed gains in:
    • Total sleep
    • Deep sleep
    • Reduced sleep latency (p < 0.05)
  • Urinary GABA levels increased within 7 days and remained stable through week 6
  • Higher GABA levels correlated with better sleep quality and improved mood
  • 40% of participants reported reduced night sweat severity
  • No adverse effects or GI symptoms were reported

Why LP815 is different?

LP815 is a proprietary strain of Lactiplantibacillus plantarum selected from over 250 million variants for its ability to produce high levels of gamma-aminobutyric acid (GABA) in the gut.

Unlike conventional supplements, LP815:

  • Produces GABA inside the GI tract
  • Works with existing gut microbiota
  • Targets the gut–brain axis, the signaling pathway between the gut and central nervous system

This positions LP815 within the emerging category of precision probiotics designed for neurological and behavioral outcomes.

Strategic significance

Sleep and stress supplements remain crowded but poorly differentiated. LP815 introduces human clinical evidence, biomarker validation, and wearable-confirmed outcomes, raising the bar for science-backed formulations.

The ingredient is now available for integration into sleep and stress supplement brands.

Industry takeaway

The study reinforces a broader shift toward:

  • Clinically validated functional biotics
  • Gut–brain axis modulation beyond digestion
  • Precision strain selection over generic probiotics

As consumer demand moves toward measurable outcomes, LP815 signals how probiotics may evolve into targeted neuro-support ingredients rather than wellness generalists.

About Verb Biotics

Verb Biotics is a B2B biotechnology company supplying clinically validated microbiome ingredients to:

  • Functional food and beverage brands
  • Dietary supplement companies
  • Companion animal health brands

The company combines advanced biology and machine learning to develop targeted biotics for digestive health, immunity, mood, stress resilience, and sleep.

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