Bayer and Broad Institute of MIT and Harvard extend research collaboration to develop new cancer therapies

Bayer and the Broad Institute of MIT and Harvard announced that they have extended their research collaboration of 10 years by an additional five years, to develop and advance innovative cancer treatments. The expanded agreement will focus on joint cancer target identification and discovery of new therapeutic approaches in oncology.

“We are constantly working to discover novel ways to treat this devastating disease affecting millions of people worldwide. Our joint goal is to bring innovation to cancer patients by building a robust, sustainable pipeline in oncology,” said Dominik Ruettinger, M.D., Ph.D., global head of research and early development for oncology, pharmaceuticals division, Bayer AG. “Bayer’s established collaboration with the Broad Institute has already resulted in three clinical oncology candidates. We look forward to continuing our work with renowned Broad scientists to advance additional innovative cancer targets into clinical development.”

Established in 2013, the longstanding collaboration combines the Broad Institute’s expertise in cancer research and chemical biology with Bayer’s in-depth experience in small, chemically manufactured molecules and biologics drug discovery to advance drug discovery research for novel cancer treatments. Both parties will continue their work on identifying additional investigational drugs for new oncology targets and treatment options.

“In order to make a meaningful impact in the lives of patients, academia and industry need to partner and draw on each other’s expertise,” said William Sellers, core member of the Broad Institute and director of the cancer programme. “Through this alliance, Broad and Bayer have done just that. Combining Broad’s expertise in cancer biology and state-of-the-art drug discovery methods with Bayer’s expertise in drug development greatly increases our power to bring transformative medicines to cancer patients.”

Derived from this strategic research alliance, Bayer’s mutant EGFR/HER2 inhibitor, currently in phase I of clinical trials, is the first reversible small molecule inhibitor targeting EGFR exon 20 insertion mutations and HER2 activating mutations in clinical testing. Bayer has presented its early oncology portfolio at major cancer research conferences this year, including the American Association for Cancer Research (AACR), the American Society of Clinical Oncology (ASCO) and most recently presented the mutant EGFR/HER2 inhibitor at the European Society for Medical Oncology (ESMO).

Academic collaborations are firmly anchored in Bayer's research and development strategy, with the aim of bringing novel treatment approaches to patients, particularly in therapeutic areas with high unmet medical need. Bayer’s strategic approach in oncology is based on precision drug development which enables fast identification of the most promising targets and commercially viable programs. The company focuses on expanding the druggable target pool, developing efficacious and “kinder”, better tolerated medicines, as well as addressing drug resistance.

Bayer with its Bayer Research & Innovation Centre (BRIC) is closely located to the Broad Institute in Kendall Square, Cambridge, MA. BRIC houses a centre of precision oncology research equipped with state-of-the-art laboratories for the development of targeted next-generation cancer therapies for patients. In addition, the centre comprises a newly established research team focused on leveraging chemical biology techniques to further propel the company’s oncology drug development process.

Financial details have not been disclosed.

Bayer is a global enterprise with core competencies in the life science fields of health care and nutrition. Its products and services are designed to help people and the planet thrive by supporting efforts to master the major challenges presented by a growing and aging global population.

Optimize Your trial insights with Clival Database.

Are you exhausted from the uncertainty of trial insights pricing? Clival Database ensures the clarity in the midst of the global scenario for clinical trials to you.

Clival Database is one of the best databases that offers an outstanding number of clinical trial data in terms of 50,000+ molecules and from primary regulatory markets as well as new entrants like Indian and Chinese markets.

With Clival, you get accurate positioning of historical sales data, patent database, company profiling, safety & efficacy, and prediction of launch of new innovative molecules helping you to align your research and driving down the cost.

To add value, we further break down our analytics for you so that improving your operational effectiveness; optimizing your clinical trials; and offering you accurate and high-quality data at lowest possible prices becomes possible.

Elevate your trial success rate with the cutting-edge insights from Clival database.

Check it out today and make more informed sourcing decisions! Learn More!